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Tadalafil Treatment in Patients With Cerebral Small Vessel Disease: The . . . BACKGROUND: White matter hyperintensities and reduced cerebral blood flow are hallmarks of cerebral small vessel disease (CSVD) We tested the feasibility of daily treatment with the vasoactive drug tadalafil in patients with CSVD and its effects on cognition and imaging markers of CSVD METHODS: The ETLAS-2 Trial was a randomized, placebo-controlled, double-blind, parallel phase II trial
Feasibility of high-dose tadalafil and effects on insulin resistance in . . . We performed a double-blind RCT in patients with T2D and assessed whether tadalafil is better than placebo to reverse insulin resistance, and feasible as an antidiabetic agent in T2D Tadalafil did not significantly improve insulin resistance expressed as GDR during glucose clamp
The efficacy and safety of tadalafil in the management of erectile . . . Therefore, since ED, a PVD, is common in patients with diabetes, further studies on the effects of daily low-dose tadalafil therapy on PVD are necessary Additional studies on the relationship between tadalafil and capillary pressure are also needed