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49ers playoff odds after ugly win over Panthers keep pace in NFC 49ers playoff chances after ugly win over Panthers keeps pace in NFC The San Francisco 49ers improved to 8-4 on Monday Night Football, but reaching the postseason will still prove to be tough
San Francisco 49ers at Cleveland Browns, Preview, Odds, Picks and . . . San Francisco 49ers vs Cleveland Browns Picks 49ers vs Browns Spread Pick Cleveland Browns +4 5 (5 units) The 49ers are coming off of a short week of practice after playing on Monday night They came away with the win against Carolina, but it wasn’t perfect Brock Purdy tossed three interceptions and he is likely to turn the ball over again versus the Browns Cleveland’s defense is elite
49ers have ‘by far’ the best odds to go worst to first in 2025 The San Francisco 49ers didn’t have the season they envisioned in 2024 After three straight NFC Championship appearances, the team fell short last season, going 6-11 and finishing the year 1-6
San Francisco 49ers Odds: Week 13 Spread, Futures, Props San Francisco 49ers odds to win the Super Bowl Last update: November 2025 When Draftkings, BetMGM, and other popular betting sites released Super Bowl 60 odds in January, the 49ers were at +2000 San Francisco’s current odds to win the 2026 Super Bowl are listed below