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Neuromuscular Home Page Basic Other · Neuromuscular disease · Dystrophin Related proteins · Myopathy-related proteins · Muscle proteins: Contractile + · Mitochondrial pathways · Fatty acid oxidation · Immunotherapy · Google · PubMed · OMIM · Proteins · WU Library · Neuromuscular Index · Neuromuscular Site · Syndromes · Pathology · Molecules
Neuromuscular Clinical Laboratory Most common preparation Useful for: Inflammatory cells Deficiencies: Fine structure; Myelin pathology; Axon loss Ultrastructure: When necessary Requisition form: Printable PDF Nerve biopsies: Information Certification: Alan Pestronk MD Neuromuscular Pathology Training Program
Serum Requisition - Washington University in St. Louis Additional antibodies include IgM binding to histone H3 and or GD1a ganglioside and IgG binding to sulfatide and or GM1 ganglioside The values of the additional antibody titers are listedon the report Interpretations are provided for all antibody tests Street address: Neuromuscular Laboratory, 509 South Euclid, Room 404, St Louis, MO 63110
NEUROMUSCULAR PERSONNEL The Neuromuscular Clinical Laboratory provides Antibody testing Antibodies tested Test request form Neuromuscular pathology (Muscle Nerve biopsies) We evaluate more than 600 muscle 100 nerve biopsies each year
Motor Syndromes - Washington University in St. Louis Paraneoplastic Lower Motor Neuron Syndrome 8, 25 Epidemiology: Single patient, 72 year old female Onset: 4 months before diagnosis of tumor Clinical Weakness Asymmetric at onset Arms Legs Severe Lower motor neuron only Bulbar: Hypophonia; Dysphagia; Unilateral facial paresis Painless Course Progressive over months Improvement after tumor removal Long-term residual disability Sensation
Polyneuropathy Differential Diagnosis Index Search Myopathy Neuropathy Synapse CNS Lab tests Basic Subcellular Washington University Go to Differential Diagnosis of Myopathies Return to Neuromuscular Home Page or newly revised Other revisions 11 18 2025
Requisitions - Washington University in St. Louis Washington University, St Louis Biopsies, Muscle Nerve (pdf) Histochemistry Biochemistry Mitochondrial oxidative enzymes Glycogen pathways Dystrophy Aggregates Immune panel Freezing instructions Other instructions Antibody testing Types of antibodies measured Requisition form (pdf) Instructions for sending serum
NEUROMUSCULAR CLINICAL LABORATORY NEUROMUSCULAR CLINICAL LABORATORY: Antibody Information To obtain antibody testing: · Draw blood in a red top tube · Send: 2 to 3 ml of serum · Send with requisition, at room temp (freezing is not necessary), via overnight mail to Neuromuscular Clinical Lab: Pestronk Washington University Medical School Department of Neurology, Box 8111
GBS - Washington University in St. Louis Return to Neuromuscular Syndromes Return to Acute Neuromuscular disorders Return to Neuromuscular Home Page References 1 Muscle Nerve 1999;22:1607-1610 2 Brain 2000;123:116-124 J Neuroimmunol 2001;113:260-267 3 Neurology 2000;54:1000 4 Neurology 2000;54:1661-1665 5 Brain 2000;123:2171-2178 6 Neurology 2001;56:1104-1106, Front Neurol 2023