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Nonalcoholic fatty liver disease - Symptoms and causes Nonalcoholic fatty liver disease, often called NAFLD, is a liver problem that affects people who drink little to no alcohol In NAFLD, too much fat builds up in the liver It is seen most often in people who are overweight or obese NAFLD is becoming more common, especially in Middle Eastern and Western nations as the number of people with obesity rises It is the most common form of liver