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AAN 2025: Long-term Onapgo cuts advanced Parkinson’s off time All of the investigators involved in the new clinical study are Supernus employees or have served as paid consultants to the pharmaceutical INFUS-ON was an open-label study that assessed the safety and efficacy of Onapgo in 99 adults with advanced Parkinson’s at 19 sites in the U S Participants had a mean age of 61 6, and a mean disease
Onapgo (apomorphine hydrochloride infusion) | Parkinsons Disease Pros Because Onapgo is delivered continuously through an under-the-skin infusion, the medication bypasses the gastrointestinal track and directly enters the brain, stimulating dopamine receptors — potentially leading to more predictable symptom improvement Researchers evaluated Onapgo in the Phase III TOLEDO clinical trial
FDA Approves Supernus Pharmaceuticals’ Onapgo for Managing Motor . . . The FDA has approved Supernus Pharmaceuticals’ Onapgo (apomorphine hydrochloride) injection, the first and only subcutaneous apomorphine infusion device for managing motor fluctuations in adults with advanced Parkinson disease (PD) According to the company, Onapgo will offer continuous drug delivery via a small wearable device, providing an alternative to invasive surgical options Approval
ONAPGO™ - Official Patient Website ONAPGO (apomorphine HCl) injection, for sc infusion is a continuous treatment of motor fluctuations (OFF episodes) in Parkinson’s disease patients
ONAPGO: A Newly-Approved Medication for OFF Periods in Parkinson’s ONAPGO TM: A Newly-Approved Medication for OFF Periods in Parkinson’s Breaking News! The first subcutaneous (under the skin) apomorphine infusion, now called ONAPGO TM, was approved by the Food and Drug Administration (FDA) on February 4, 2025 Apomorphine is a dopamine agonist whose effects have a rapid onset It has been available in the US as a subcutaneous injection, known as Apokyn
SPN-830, now Onapgo, approved for advanced Parkinson’s disease Long road to Onapgo’s approval Despite these demonstrated benefits, Supernus has faced challenges in getting the therapy approved by the FDA The company first applied for SPN-830’s approval in 2020, but regulators said the application lacked sufficient data for review