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Poly (A)-specific ribonuclease - Wikipedia Poly (A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is encoded by the PARN gene [5][6]
Poly (A)-specific ribonuclease (PARN): More than just “mRNA stock . . . Although PARN has been primarily known as the regulator of the stability of mRNAs, recent studies indicate that PARN has multiple roles including the regulation of TP53 pathway, ribosome biogenesis and maturation of 3′-end of the telomerase RNA component
Entry - *604212 - POLYADENYLATE-SPECIFIC RIBONUCLEASE; PARN - OMIM HGNC Approved Gene Symbol: PARN The PARN gene, which belongs to a highly conserved family of exoribonucleases, acts by shortening mRNA poly (A) tail length through the process of deadenylation, thus regulating gene expression (summary by Tummala et al , 2015)
Germline PARN Variants in Telomere Biology Disorders and Challenges in . . . PARN encodes poly (A)-specific ribonuclease, a 3 exoribonuclease important in regulating RNA stability and maturation Rare germline PARN variants have been reported in telomere biology disorders (TBDs) leading to its inclusion on gene panels for bone marrow failure syndromes and pulmonary diseases
Gene - PARN Poly (A)‐specific ribibonuclease (PARN) is a key 3′ exoribonuclease that initiates mRNA decay by specifically removing poly (A) tails, thereby regulating mRNA stability and translation
Orphanet: PARN-poly(A)-specific ribonuclease The documents contained in this website are presented for information purposes only The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment Orphanet is part of the Gene Curation Coalition, a global effort to harmonise gene-level resources