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Johnson Johnsons dual-targeting CAR T-cell therapy shows encouraging . . . Johnson Johnson (NYSE: JNJ) announced today the first clinical data from an ongoing Phase 1b study for JNJ-90014496 (JNJ-4496), an investigational dual-targeting anti-CD19 CD20 bispecific autologous chimeric antigen receptor (CAR) T-cell therapy, being studied in patients with relapsed or refractory large B-cell lymphoma (R R LBCL) who have not been previously treated with CAR T-cell therapy
Yescarta for Relapsed or Refractory Large B-Cell Lymphoma CAR T-cell therapy, a type of personalized immunotherapy, can help cure some people with aggressive non-Hodgkin lymphoma (NHL) That’s according to updated results from a large randomized phase 3 clinical trial of the CAR T-cell therapy axicabtagene ciloleucel (Yescarta) Most people diagnosed with diffuse large B-cell lymphoma, the most common form of aggressive NHL, will be cured by
Johnson Johnson Reports Promising Dual CAR-T Cell Therapy Data of . . . In a breakthrough for oncology, Johnson Johnson has announced promising early results from a Phase 1b clinical trial for its second-generation CAR T-cell therapy, JNJ-90014496 (also referred to as JNJ-4496) The treatment has been demonstrated to have a strong success rate for treating patients who have relapsed or are refractory to large B-cell lymphoma (R R LBCL), a particularly aggressive
Trial of cell-based therapy for high-risk lymphoma leads to FDA . . . The researchers collected immune cells called T cells from 38 patients with large B-cell lymphoma whose cancers had started growing after previous therapies including chemotherapy All but one of the patients had also progressed after CAR-T therapy targeting CD19; the cancer cells of the one remaining patient did not express CD19 on their surfaces
Efficacy and safety of a novel CD19, CD22 dual-targeted fully human . . . Chimeric antigen receptor (CAR) T-cell therapy represents one of the most significant breakthroughs in treating relapsed or refractory B cell malignancies [1,2,3,4,5,6,7] To date, six CD19-targeted CAR-T products have been approved by the U S Food and Drug Administration (FDA) or the National Medical Products Administration (NMPA) for the treatment of relapsed refractory B cell non-Hodgkin