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Genome-wide cell-free DNA fragmentation in patients with . . . Here we developed an approach to evaluate fragmentation patterns of cell-free DNA across the genome, and found that profiles of healthy individuals reflected nucleosomal patterns of white blood cells, whereas patients with cancer had altered fragmentation profiles
Genome-wide cell-free DNA fragmentation profiling for early . . . Conclusions: This effort is the first study to demonstrate genome-wide cell-free DNA fragmentation abnormalities in patients with cancer Results of these analyses highlight important properties of cfDNA and provide a facile approach for screening, early detection, and monitoring of human cancer
Genome-wide cell-free DNA fragmentation in patients with cancer We developed an approach to evaluate fragmentation patterns of cfDNA across the genome and found that cfDNA profiles of healthy individuals reflected nucleosomal patterns of white blood cells, while patients with cancer had altered fragmentation profiles
Detection of Brain Cancer Using Genome-wide Cell-free DNA . . . A machine learning approach leveraging genome-wide cfDNA fragmentation profiles enables noninvasive detection of gliomas, capturing signals from tumor-derived DNA and changes in immune cell populations
Genome-wide cell-free DNA fragmentation in patients with cancer Here we developed an approach to evaluate fragmentation patterns of cell-free DNA across the genome, and found that profiles of healthy individuals reflected nucleosomal patterns of white blood cells, whereas patients with cancer had altered fragmentation profiles