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DNA polymerase mu - Wikipedia DNA polymerase mu DNA polymerase mu is a polymerase enzyme found in eukaryotes In humans, this protein is encoded by the POLM gene [5]
POLM Gene - GeneCards | DPOLM Protein | DPOLM Antibody POLM (DNA Polymerase Mu) is a Protein Coding gene Diseases associated with POLM include Congenital Myopathy 2A, Typical, Autosomal Dominant and Xeroderma Pigmentosum, Variant Type
Entry - *606344 - POLYMERASE, DNA, MU; POLM - OMIM POLM is a template-dependent DNA polymerase closely related to the lymphoid-specific enzyme terminal deoxynucleotidyltransferase (TDT; 187410) POLM appears to participate in the processing of DNA ends during immunoglobulin (Ig) gene rearrangement (Bertocci et al , 2003)
POLM variant G312R promotes ovarian tumorigenesis through genomic . . . We uncover the POLM G312R mutation as a driver of genomic instability in ovarian cancer via aberrant ribonucleotide incorporation We reveal that POLM G312R upregulates COL11A1 and activates NF-κB signaling, contributing to tumor progression and chemoresistance
POLM DNA polymerase mu - NIH Genetic Testing Registry (GTR) - NCBI Clinical resource with information about POLM, and available tests There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials gov
27434 - Gene ResultPOLM DNA polymerase mu [ (human)] GeneRIFs: Gene References Into Functions DNA Polymerase and dRP-lyase activities of polymorphic variants of human Pol iota Mechanism of genome instability mediated by human DNA polymerase mu misincorporation DNA polymerase mu: An inflexible scaffold for substrate flexibility pol mu-mediated deoxyguanosine triphosphate mismatch insertion opposite template base T coupled with ligation could