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2024 neuroscience research in review | Wu Tsai Neurosciences Institute Aug 22 2024 | Knight Initiative for Brain Resilience A team of neuroscientists at the Knight Initiative for Brain Resilience have zeroed in on a critical regulator of brain metabolism that may be over-activated in the brains of patients with Alzheimer’s disease Minhas et al, Nature (2024)
Targeting the kynurenine pathway - Nature Minhas, P S et al Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies Science 385, eabm6131 (2024)
Drugs that improve brain metabolism could help Alzheimer’s patients Minhas et al, Nature (2024) Researchers showed that mice with a genetic model of Alzheimer's disease lose glucose metabolism in the memory region of the hippocampus (center: 'APP PS1' vs left: 'control'), but IDO1 inhibitor drugs restore normal metabolic levels (right: 'APP PS1 + IDO1 inhibitor')
Racial and ethnic disparities in cardiovascular disease - analysis . . . In this analysis of multiple publicly available datasets, we sought to examine racial and ethnic disparities in different aspects of CVD, CVD-related risk factors, CVD-related morbidity and mortality, and CVD trainee representation in the US
2024 Frank Reidy Research Center for Bioelectrics Retreat Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer deaths worldwide, marked by its aggressive behavior and therapeutic resistance Despite advancements in cancer research, effective treatment options remain limited, highlighting the urgent need for innovative approaches