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Analysis of Tumor Microenvironment Heterogeneity among Breast Cancer . . . Our study reveals the breast cancer tumor microenvironment heterogeneity across subtypes The comprehensive analysis of breast cancer TME-related characteristics may help us to adopt a tailored treatment strategy for different subtypes of patients
Influence of tumor microenvironment on the different breast cancer . . . In this review, we present a description of the multiple therapeutic options used for different breast cancer subtypes, as well as the influence that the TME may exert on the development of the disease and on the response to the distinct therapies, which in some cases may explain their failure by the occurrence of relapses and resistance
Heterogeneity of the Tumor Microenvironment Across Molecular Subtypes . . . Breast cancer is a heterogenous disease at the molecular level thus, it can be hypothesized that different molecular subtypes differ in their tumor microenvironment (TME) also Understanding the TME heterogeneity may provide new prognostic biomarkers and new targets for cancer therapy
Differences in tumor microenvironment between HER2-positive and HER2 . . . Conclusions: Our research indicates that the patterns of immune cell subtypes in different types of early breast cancer are different Further exploration of the immune microenvironment in different molecular types of breast cancer may provide additional targets for immunotherapy
Intra-tumoral spatial heterogeneity in breast cancer quantified using . . . Breast cancer is a highly heterogeneous disease where variations of biomarker expression may exist between individual foci of a cancer (intra-tumoral heterogeneity) The extent of variation of biomarker expression in the cancer cells, distribution of cell types in the local tumor microenvironment and their spatial arrangement could impact on diagnosis, treatment planning and subsequent
The Tumor Immune Microenvironment in Breast Cancer Progression Results: In breast cancer, tumors exhibit increased immune cell infiltration compared to normal tissue Variations exist across subtypes, with higher levels observed in triple-negative and HER2+ tumors are linked to better survival In contrast, ER+ tumors display lower immune infiltration, associated with poorer outcomes
Multi-omics analyses of the heterogenous immune microenvironment in . . . Triple-negative breast cancer (TNBC) is commonly characterized by high-grade and aggressive features, resulting in an augmented likelihood of distant metastasis and inferior prognosis for patients Tumor immune microenvironment (TME) has been recently considered to be tightly correlated with tumor progression and immunotherapy response However, the actual heterogenous TME within TNBC remains
Breast Cancer and Tumor Microenvironment: The Crucial Role of Immune . . . In breast cancer, the TME plays a critical role in tumor progression, metastasis, and resistance to therapies It is composed of immune cells, fibroblasts, endothelial cells, and the extracellular matrix, which interact with tumor cells through direct contact and soluble factors [2]