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Stevens Johnson Syndrome Toxic Epidermal Necrolysis. SJS TEN Stevens–Johnson syndrome toxic epidermal necrolysis, Lyell syndrome, Erythema multiforme exudativum, Ectodermosis erosiva pluriorificialis Authoritative facts from DermNet New Zealand
Stevens Johnson syndrome toxic epidermal necrolysis: nursing management What is Stevens Johnson syndrome toxic epidermal necrolysis? Stevens Johnson syndrome toxic epidermal necrolysis (SJS TEN) is a very severe and acute skin disease, almost always caused by a drug SJS TEN is characterised by an extensive necrosis and detachment of the epidermis, which involves skin and mucosal surfaces (genitals, eyes, and mouth) The nursing care described on this page is
Erythema multiforme - DermNet Erythema multiforme is an immune-mediated, typically self-limiting, mucocutaneous condition characterised by ‘target’ lesions as seen in the images below Treatment is often not needed as episodes are typically self-limiting with no ongoing complications
Drug hypersensitivity syndrome. DRESS - DermNet Drug hypersensitivity syndrome, Drug reaction with eosinophilia and systemic symptoms, DRESS, Drug induced hypersensitivity syndrome, DIHS, DRESS syndrome Authoritative facts from DermNet New Zealand
Nikolskys Sign - DermNet Using Nikolsky’s original definition strictly, his eponymous sign is the physical splitting of the epidermis creating an erosion (partial loss of the epidermis) following the application of a shearing force to the surface of the skin seen in pemphigus foliaceus However, with time the use of the sign has broadened to include other intraepidermal disorders including pemphigus vulgaris and it
Drug hypersensitivity syndrome. DRESS It may have overlapping features with Stevens–Johnson syndrome toxic epidermal necrolysis (SJS TEN) and acute generalised exanthematous pustulosis (AGEP) Who gets drug hypersensitivity syndrome? Drug hypersensitivity syndrome is relatively rare It mainly affects adults and is equal in incidence in males and females
Morbilliform drug reaction (maculopapular drug eruption) - DermNet What is morbilliform drug reaction? Morbilliform drug eruption is the most common form of drug eruption Many drugs can trigger this allergic reaction, but antibiotics are the most common group The eruption may resemble exanthems caused by viral and bacterial infections A morbilliform skin rash in an adult is usually due to a drug In a child, it is more likely to be viral in origin
Erythema multiforme: histological features and mechanisms Histology of erythema multiforme A skin biopsy of erythema multiforme (EM) may show in the epidermis epithelium: Apoptotic individual keratinocytes (cellular self-destruction, earliest histological change) Hydropic degeneration of basal keratinocytes (swollen degenerating cells at the base of the epidermis) Intercellular oedema (spongiosis) Blisters within and under the epidermis epithelium
SJS-TEN images - DermNet SJS-TEN images Images of Stevens Johnson syndrome toxic epidermal necrolysis Authoritative facts from DermNet New Zealand