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Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 . . . Background: Retatrutide (LY3437943) is an agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and glucagon receptors Its dose-response relationships with respect to side effects, safety, and efficacy for the treatment of obesity are not known
Triple-hormone receptor agonist retatrutide significantly improves . . . In a phase 2 study in participants who have obesity or overweight but not type 2 diabetes (T2D) (n=338), retatrutide (RETA), an agonist of GIP, GLP-1 and glucagon receptors, reduced body weight, glycated hemoglobin, triglycerides (TG), LDL-C and VLDL-C
TRIPLE HORMONE RECEPTOR AGONIST RETATRUTIDE RESOLVES STEATOSIS . . . - AASLD Background: Retatrutide (RETA; LY3437943) is a novel triple agonist of the GIP, GLP-1 and glucagon receptors under investigation for obesity treatment A 48-week phase 2 obesity study demonstrated weight loss of −22 8% and −24 2% with RETA 8 and 12 mg
American Diabetes Association Highlights Novel Agent Retatrutide which . . . The Triple–Hormone-Receptor Agonist Retatrutide for Obesity Phase 2 Trial was designed to look at the efficacy and safety of retatrutide for the treatment of obesity and comes at a time when it is projected that by 2030, nearly 1 in 2 Americans will have obesity
Retatrutide (GLP-3) Next-Gen Triple-Agonist for Obesity Diabetes A deep dive into retatrutide, a triple-agonist targeting GLP-1, GIP, and glucagon receptors This article analyzes the clinical trial data on its significant weight loss effects and metabolic benefits, explaining its mechanism and comparing it to other leading peptide therapeutics