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Stevens Johnson syndrome toxic epidermal necrolysis: nursing management What is Stevens Johnson syndrome toxic epidermal necrolysis? Stevens Johnson syndrome toxic epidermal necrolysis (SJS TEN) is a very severe and acute skin disease, almost always caused by a drug SJS TEN is characterised by an extensive necrosis and detachment of the epidermis, which involves skin and mucosal surfaces (genitals, eyes, and mouth) The nursing care described on this page is
SJS-TEN images - DermNet SJS-TEN images Images of Stevens Johnson syndrome toxic epidermal necrolysis Authoritative facts from DermNet New Zealand
Erythema multiforme - DermNet Erythema multiforme is an immune-mediated, typically self-limiting, mucocutaneous condition characterised by ‘target’ lesions as seen in the images below Treatment is often not needed as episodes are typically self-limiting with no ongoing complications
Nikolskys Sign - DermNet The term “pseudo Nikolsky” sign or “Nikolsky’s test” has been applied to Stevens-Johnson syndrome toxic epidermal necrolysis where the full epidermis is involved but a shearing force propagates the blister Who was Pyotr Vasilyevich Nikolsky? Pyotr Vasilyevich Nikolskiy (1858-1940) was born in Usman, Russia
Dermatological emergencies. Toxic epidermal necrolysis Created 2008 Learning objectives Recognise toxic epidermal necrolysis and its causes Clinical features Toxic epidermal necrolysis (T E N ) is characterised by fever (>38C), widespread tender erythema affecting >30% skin surface associated with mucosal involvement Erythema is followed by extensive full thickness cutaneous and mucosal necrosis and denudation within 2 or 3 days Similar
Toxic epidermal necrolysis pathology Toxic epidermal necrolysis (TEN) is a severe cutaneous drug reaction characterised by a prodromal 'flu-like illness followed by the rapid appearance of a painful erythematous rash and desquamation of skin and mucous membranes TEN is at the severe end of a spectrum with Stevens-Johnson syndrome defined by >30% body surface area skin detachment Histology of toxic epidermal necrolysis In TEN
Adverse cutaneous reactions to psychotropic drugs - DermNet Stevens–Johnson syndrome toxic epidermal necrolysis Stevens–Johnson syndrome toxic epidermal necrolysis (SJS TEN) is a severe, life-threatening illness with blistering of the mouth and other mucous membranes and widespread macular rash, with detachment of the epidermis from the dermis Psychotropic medications like alprazolam, duloxetine, sertraline and anticonvulsant medications can cause
Severe cutaneous adverse reaction - DermNet What is a severe cutaneous adverse reaction? A severe cutaneous adverse reaction, or SCAR, refers to several distinct conditions Acute generalised exanthematous pustulosis (AGEP) Drug-induced hypersensitivity syndrome (DIHS), also known as drug reaction with eosinophilia and systemic symptoms (DRESS) Stevens–Johnson syndrome toxic epidermal necrolysis (SJS TEN) Common features can be seen
Dermatological emergencies. Erythema multiforme Created 2008 Learning objectives Diagnose, classify and manage erythema multiforme Introduction Erythema multiforme (EM) is conventionally separated into EM minor and EM major It is now separated from Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (T E N ) Clinical features EM minor EM is more common in men than women and 50% are under 20 years of age It is an eruption of