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pgen. 1003235 1. . 9 - PLOS Unlike other multivariate methods, TATES detects both genetic variants that are common to multiple phenotypes and genetic variants that are specific to a single phenotype, i e TATES provides a more complete view of the genetic architecture of complex traits
The labor market outcomes of bilinguals in the United States . . . - PLOS At least half of the world population is bilingual, but lifetime financial gains from early exposure to multiple languages are largely unknown In this study, we analyze individual earnings of bilinguals in the US using 15 years of Census data and an augmented wage model, accounting for cognitive, manual, and interpersonal skills derived from O*NET job task descriptors via sparse principal
Many roads to minimizing regret: A comparison of Wang et al (2024) and . . . Wang et al (2024) [1] introduce a powerful extension to their model of the basal ganglia, in which dopamine (DA) encoding of novelty facilitates efficient uncertainty-driven exploration The model builds on previous formulations in which direct and indirect (D1 and D2) striatal pathways represent the mean and variance of reward distributions [2] The new model suggests that dopaminergic
Evaluation of potentially toxic elements and ecological risks . . . Mining environmental liabilities (MELs) are abandoned deposits resulting from extractive activities that pose a high risk of contamination and remain an unresolved challenge for authorities worldwide This study evaluated the contamination levels of potentially toxic elements (PTEs) and their associated ecological risks in MELs, using multiple environmental indices Analyses were performed
Universal health coverage—Exploring the what, how, and why using . . . Universal health coverage (UHC) is a critical target in many health system strategies to achieve ‘good health and wellbeing’ Evidence on the meaning and scope of UHC and the strategies required to achieve it are needed, as variations in its understanding and implementation have risen This realist review was conducted to fill the knowledge gap by synthesising evidence on the meaning
The safe development paradox of the United States regulatory floodplain In the United States, requirements for flood insurance, development restrictions, and federal buyout program eligibility rely on regulatory designation of hazardous zones, i e , inside or outside the 100-year floodplain Extensive research has investigated floodplain development patterns across different geographies, times, and scales, yet the impacts, and potential unintended consequences, of
Adolescent extracurricular activities and perception of risk of harm . . . Related studies on alcohol use suggest that extracurricular activity par-ticipation often leaves less unscheduled time for adolescents to drink alcohol [26] and facili-tates the forging of relationships with mentors and adults who might serve as role models for healthy behaviors regarding substance use [26]
Exploring the impact of drug decriminalization and legalization . . . As countries increasingly adopt more liberal drug policies, concerns have emerged about their broader health and social impacts A complex bidirectional relationship exists between problematic drug use and mental health conditions This is particularly evident in the co-occurrence of mental health disorders with substance use disorders (SUDs) However, the broader mental health effects of drug