copy and paste this google map to your website or blog!
Press copy button and paste into your blog or website.
(Please switch to 'HTML' mode when posting into your blog. Examples: WordPress Example, Blogger Example)
Input Form:Deal with this potential dealer,buyer,seller,supplier,manufacturer,exporter,importer
(Any information to deal,buy, sell, quote for products or service)
LY3954068 | ALZFORUM LY3954068 is a small interfering RNA (siRNA) that targets expression of the microtubule-associated binding protein tau No information is available about the makeup of LY3954068
A Tale of Two T Cells—Slowing Tau Spread, Shredding White Matter With T cells sidelined in these CD8 knockouts, tau pathology went on the offensive By 30 weeks of age, phospho-tau had spread deeper into the brain than in CD8-intact controls (image below) Michal Schwartz of the Weizmann Institute of Science in Rehovot, Israel, noted that these findings run counter to conventional thinking
Triple Trouble: New Knock-in Turbocharges Tauopathy They accumulated hyperphosphorylated tau in their brains and lost synapses by approximately 15 months of age, but they had no tau oligomers capable of seeding aggregates Such “seeds” are a hallmark of human tauopathies Recognizing the need for models with more robust pathology at a younger age, the authors engineered the new triple-knock-ins
ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles To find out, the scientists turned to surface plasmon resonance, a technique that quantifies molecular interactions in real time It showed that ApoE3Ch clings onto tau monomers immobilized on sensor chips approximately eight times more tightly than does wild-type ApoE3 Similarly, in neuroblastoma cells, glutathione S-transferase-labelled tau and GFP-tagged ApoE3Ch bound tightly (image at right)
Tau (CP-13) - ALZFORUM This monoclonal antibody, generated against paired helical filaments (PHFs) isolated from Alzheimer’s brains, recognizes tau phosphorylated at serine 202 Recognizes tau phosphorylated at serine 202 Immunoreactivity present in Alzheimer’s disease and other tauopathies Immunoreactivity absent in
Widely Used Tau Seeding Assay Challenged - ALZFORUM Many research groups study tau misfolding and propagation using in vitro models, but interpreting findings from artificial systems can be dicey In a preprint on bioRxiv, researchers led by Eckhard Mandelkow at the German Center for Neurodegenerative Diseases, Bonn, question whether a widely used
Gosuranemab - ALZFORUM Background This is a humanized IgG4 monoclonal anti-tau antibody In April 2014, Bristol-Myers Squibb acquired iPierian, a biotechnology company that had developed IPN007, an antibody against extracellular, N-terminal fragments of tau (eTau) that were originally isolated from familial AD patient-derived pluripotent stem cells The rationale for this therapeutic approach is that eTau is
Tau (MC-1) - ALZFORUM The interaction of MC-1 with recombinant tau suggests that post-translational modifications are not required to generate the MC-1 epitope However, it remains possible that post-translational modifications influence the ability of tau to adopt or maintain the conformation seen by MC-1
HMTM - ALZFORUM Tau pathology is widely considered to be downstream of Aβ pathology and is more closely linked to cognitive deficits in Alzheimer's disease Mutations in the tau gene cause frontotemporal dementia, not Alzheimer's disease, but tau is considered a central drug target for all tauopathies, including Alzheimer's