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Pyruvate dehydrogenase complex - Wikipedia Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that converts pyruvate into acetyl-CoA by a process called pyruvate decarboxylation [1] Acetyl-CoA may then be used in the citric acid cycle to carry out cellular respiration, and this complex links the glycolysis metabolic pathway to the citric acid cycle
The Pyruvate Dehydrogenase Complexes: Structure-based Function and . . . In mammals, PDC plays the role of a gatekeeper in the metabolism of pyruvate to maintain glucose homeostasis during the fed and fasting states The flux through PDC is tightly regulated in tissues under different metabolic conditions
Pyruvate Dehydrogenase Complex and TCA Cycle When transported into the inner mitochondrial matrix, pyruvate encounters two principal metabolizing enzymes: pyruvate carboxylase, PC (a gluconeogenic enzyme) and pyruvate dehydrogenase (PDH), the first enzyme of the PDH complex (PDHc)
Pyruvate Dehydrogenase Complex - an overview | ScienceDirect Topics The pyruvate dehydrogenase complex (PDHc) is a mitochondrial matrix multienzyme complex that provides the link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the conversion of pyruvate into acetyl-CoA
The Pyruvate Dehydrogenase Complexes: Structure-based Function and . . . The pyruvate dehydrogenase complexes (PDCs) from all known living organisms comprise three principal catalytic com-ponents for their mission: E1 and E2 generate acetyl-coenzyme A, whereas the FAD NAD -dependent E3 performs redox recy-cling
Structural diversity of pyruvate dehydrogenase complexes The pyruvate dehydrogenase complex (PDHc) is a crucial metabolic enzyme complex found in all aerobic organisms It catalyzes the conversion of pyruvate, the product of glycolysis, into acetyl-CoA, a key substrate for the citric acid cycle and fatty acid synthesis
Pyruvate dehydrogenase - Wikipedia Pyruvate dehydrogenase is usually encountered as a component, referred to as E1, of the pyruvate dehydrogenase complex (PDC) PDC consists of other enzymes, referred to as E2 and E3 Collectively E1-E3 transform pyruvate, NAD +, coenzyme A into acetyl-CoA, CO 2, and NADH