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EMCrit 380 - Acid Base Part VIII - Tris-Hydroxymethyl Aminomethane . . . Tris-Hydroxymethyl Aminomethane (THAM or tromethamine) is an amino alcohol that acts as a buffer base that unlike NaBicarb doesn't increase Na or release CO2–it actually lowers PaCO2 Sounds great, huh? It is unfortunately expensive and has some other issues we will discuss
Tromethamine (THAM) Discontinuation - Stanford Health Care THAM is often used in place of sodium bicarbonate because THAM lacks the carbon-dioxide producing effects of bicarbonate THAM is capable of buffering both metabolic and respiratory acids which leads to an increase in extracellular and intracellular pH without carbon dioxide generation
THAM (tromethamine injection) | Pfizer Medical - US Tham Solution (tromethamine injection) is administered by slow intravenous infusion, by addition to pump-oxygenator ACD blood or other priming fluid or by injection into the ventricular cavity during cardiac arrest
Pfizer Tham Solution (tromethamine injection) should be administered slowly and in amounts sufficient only to correct the existing acidosis, and to avoid overdosage and alkalosis