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B cell tolerance and autoimmunity: Lessons from repertoires In recent years, our ability to analyze immune repertoires at scale has drastically increased, both through advances in sequencing and single-cell analyses Here, we review the current knowledge on B cell repertoire analyses, focusing on their implication for autoimmunity
B Cell Repertoire: Dynamics and Implications - synthorum. com The various steps in B cell development include progenitor cell stages, pre-B cell stages, and finally mature B cells Each stage is characterized by specific gene rearrangements that allow for the generation of unique B cell receptors
B-Cell Receptor Repertoire: Recent Advances in Autoimmune Diseases Furthermore, we provide a detailed summary of the latest research progress in BCR repertoire in autoimmune diseases, involving systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), primary Sjögren’s syndrome (pSS), and type 1 diabetes (T1D)
Practical guidelines for B-cell receptor repertoire sequencing analysis Here we provide a set of practical guidelines for B-cell receptor repertoire sequencing analysis, starting from raw sequencing reads and proceeding through pre-processing, determination of population structure, and analysis of repertoire properties
An Overview of B Cells – from Discovery to Therapy Mi - Bio-Rad Fig 1 Summary of early B cell development MPPs, multipotent progenitors; CLPs, common lymphoid progenitors; BM, bone marrow; RAG, recombinase activating genes; TdT, terminal deoxynucleotidyl transferase; SLC, surrogate light chain; BCR, B cell receptor
Structural diversity of B-cell receptor repertoires along the B-cell . . . Our results establish the CDR structure differences in BCR repertoires and have applications for many fields including immunodiagnostics, phage display library generation, and “humanness” assessment of BCR repertoires from transgenic animals
The B cell repertoire In this report we will review recent developments that focus on the formation of the murine B cell repertoire This area has captured the interest of many active inves-tigators, and new information is being rapidly added to the literature
Multimodal repertoire analysis unveils B cell biology in health and . . . Here, we cataloged and investigated the repertoire of five B cell subsets from 595 cases under immune-mediated diseases and health CDR-H3 length among naïve B cells was shortened among autoimmune diseases in an interferon signature-dependent manner
The whole-organism heavy chain B cell repertoire from Zebrafish self . . . Technically, questions concerning the B cell repertoire have been limited by: (1) the scale of the system, with more than 10 12 cells in humans and a similar order of magnitude in mice; (2) an inability to measure diversity within the whole population of B cells
Developmental changes in the rules for B cell selection We discuss recent ad-vancements in the understanding of the molecular program, centered around the RNA binding protein Lin28b, that licenses self-reactive B-1 cell output during ontog-eny Finally, we speculate on the possible link between the unique rules of early life