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TNK vs tPA — The ORIGINAL Trial - REBEL EM - Emergency Medicine Blog The ORIGINAL Trial supports TNK as a safe, effective alternative to tPA for AIS, reinforcing findings from other large trials Its single-bolus administration offers clear advantages, especially in resource-limited settings
2026 Guideline for the Early Management of Patients With Acute Ischemic . . . The “2026 Guideline for the Early Management of Patients With AIS” replaces the “2018 Guidelines for the Early Management of Patients With AIS” and the 2019 update to reflect recent advances in evidence This updated guideline is intended to provide a comprehensive, up-to-date, evidence-based set of recommendations, advising management from prehospital evaluation through acute
Acute Ischemic Stroke Treatment | TNKase® (tenecteplase) Learn about TNKase® (tenecteplase) for the treatment of acute ischemic stroke (AIS) Please see full Prescribing Information for additional Important Safety Information
Study Details | NCT07375953 - ClinicalTrials. gov Details for study NCT07375953, | ClinicalTrials gov Despite being the standard pharmacological reperfusion therapy for acute ischemic stroke, intravenous thrombolysis is limited by suboptimal recanalization rates Tenecteplase (TNK), a newer thrombolytic agent, offers practical advantages over alteplase, including single bolus administration However, a significant proportion of patients fail
Genentech: TNKase® (tenecteplase) - Information for Patients Indications Important Safety Information Indication Acute Ischemic Stroke TNKase (tenecteplase) is indicated for the treatment of acute ischemic stroke (AIS) in adults Important Safety Information Contraindications TNKase is contraindicated in any patients with: Active internal bleeding Intracranial or intraspinal surgery or trauma within 2 months Known bleeding diathesis Current severe