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Acute Ischemic Stroke Treatment | TNKase® (tenecteplase) Tenecteplase is an enzyme that, when present in blood in pharmacologic concentrations, remains active under in vitro conditions This can lead to degradation of fibrinogen in blood samples removed for analysis Inform patients that bleeding can occur 1 or more days after administration of TNKase
Tenecteplase - StatPearls - NCBI Bookshelf Tenecteplase (TNK) is a single-bolus recombinant fibrinolytic agent used to manage intravascular clots The drug is in the tissue plasminogen activator (tPA) class of medications
Tenecteplase (TNK-tPA) • LITFL • CCC TNK-tPA, Metalyse, TNKase, Elaxim It comes in a set-up not-unlike Prothrombinex with a diluent and a transfer device Don’t shake it up, swirl gently It enhances the conversion of plasminogen to plasmin by binding to fibrin initiating fibrinolysis with limited systemic proteolysis
Tenecteplase Uses, Side Effects Warnings - Drugs. com Tenecteplase is used in adults to treat a stroke caused by a clot (acute ischemic stroke) and to lower the risk of death from a certain type of heart attack Tenecteplase may also be used for purposes not listed in this medication guide
TNK vs tPA — The ORIGINAL Trial - REBEL EM - Emergency Medicine Blog Several studies have demonstrated the safety and efficacy of TNK as an alternative to tPA 3–10 The ORIGINAL trial evaluated the noninferiority of TNK compared to tPA in Chinese patients with acute ischemic stroke (AIS)
Tenecteplase Thrombolysis for Acute Ischemic Stroke Tenecteplase is a fibrinolytic drug with higher fibrin specificity and longer half-life than the standard stroke thrombolytic, alteplase, permitting the convenience of single bolus administration