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RSV Vaccine Guidance for Pregnant Women | RSV | CDC CDC recommends a respiratory syncytial virus (RSV) vaccine for pregnant women to protect their babies from severe RSV disease Pregnant women should get a single dose of the maternal RSV vaccine (Pfizer’s Abrysvo) during weeks 32 through 36 of pregnancy
Respiratory syncytial virus (RSV) immunization products As of January 2025, one RSV vaccine is available for use during pregnancy: RSVpreF RSVpreF is administered during pregnancy in the third trimester to protect infants against RSV by transferring antibodies from the mother to the fetus through the placenta before birth
RSV Vaccination in Pregnancy RSV-MAT-009 stopped early due to increased risk for preterm birth; however increased risk of PTB seen only in low- middle-income countries MATISSE planned interim analysis in 2023 showed “statistically insignificant” increased risk for PTB; FDA approved only for patients 32-36 weeks GA in Aug 2023 Adapted from Dugdale et al 2025
Respiratory Syncytial Virus (RSV) - Texas Childrens In pregnant individuals who received the RSV vaccine, side effects included pain at the injection site, headache, muscle pain or nausea The vaccine is given close to the end of pregnancy which helps reduce any possible risk of very early preterm birth
RSV Immunization Options for Moms and Babies | Nemours Blog The maternal RSV vaccine (Abrysvo®) is given to pregnant mothers who are 32 to 36 weeks pregnant Abrysvo works by allowing pregnant mothers to build an immune response (antibodies called immunoglobulins) to RSV, which is then passed along to their growing baby
Clinical Guidance for RSV Immunizations and Vaccines Pregnant women should get a single dose of the maternal RSV vaccine (Pfizer’s Abrysvo) during weeks 32 through 36 of pregnancy to protect their baby from severe RSV disease