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Variant of Uncertain Significance (VUS) When analysis of a patient’s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS)
What to do if your genetic test finds a variant of uncertain . . . But sometimes, you might not get a clear “yes” or “no ” You might just get a “maybe ” “That’s what you’ll hear if you have a variant of uncertain significance, or VUS for short,” says Sara Wofford, a genetic counselor at MD Anderson The Woodlands
VUS Variant of Uncertain Significance for cancer patients . . . Some people, like you, have a Variant of Uncertain Significance (VUS) which is a genetic change that the laboratory cannot interpret VUS cannot be categorized as potentially disease causing or harmless because the meaning of this type of genetic change is not yet known
Understanding genetic variants of uncertain significance - PMC If a VUS is found to be inherited from an unaffected parent, the variant is less likely to be pathogenic If a child has two VUSs in a gene that typically cause disease in an autosomal recessive manner, testing parents will clarify if the VUSs are in the same or different copies of the gene
Assessing a Variant of Uncertain Significance (VUS) Figuring out if a VUS falls more on the benign or pathogenic side is the first step in determining how to discuss it with a patient and whether to pursue further investigation
VUS – The Most Maligned Result in Genetic Testing The classification of genetic variants, based on the ACMG guidelines, is usually a five-tiered scheme which describes the quantity and quality of evidence needed to classify the variant as pathogenic, likely pathogenic, a variant of uncertain significance (VUS), likely benign, or benign
What’s a “Variant of Uncertain Significance?” A VUS? The VUS designation means that hardly any variants have turned up that match the one in Annie’s daughter, so it can’t definitively be called benign or likely benign
VARIANT OF UNCERTAIN SIGNIFICANCE (VUS) - Genetics When a change in a gene (variant) is found but it is not known whether the variant is involved in causing the health condition for which the test was done, it is called a variant of uncertain significance (VUS)