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GEO Accession viewer NCBI's Gene Expression Omnibus (GEO) is a public archive and resource for gene expression data
Download data for GSE164522 - GEO - NCBI Download data for GSE164522 Information about GEO data organization is provided in the GEO overview GEO FTP site structure and available formats are described in README txt Additional download options are described at Download GEO data Submitter-supplied data? Series SOFT file GSE164522_family soft gz 3 8 Kb
Immune phenotypic linkage between colorectal cancer and liver . . . The tumor microenvironment (TME) is connected to immunotherapy responses, but it remains unclear how cancer cells and host tissues differentially influence the immune composition within TME Here, we performed single-cell analyses for autologous samples from liver metastasized colorectal cancer to d …
Identification and Verification of Key Genes in Colorectal Cancer Liver . . . The scRNA-seq data from GEO database GSE164522 contained gene expression matrices for 17 CRLM samples Cluster analysis of the normalized single-cell sequencing data was performed, and the results showed that 17 samples of CRLM were clustered into 23 classes (Fig 1 A)
Single-cell analysis unveils activation of mast cells in colorectal . . . To gain a deeper understanding of the changes in MCs during the tumorgenesis of CRC, we compared gene expression differences between MCs in CRC tissue and normal tissue in three single-cell datasets (GSE164522, GSE178341, and 5-cohorts) (Fig 2 b and Table S5)
Single-cell and spatial transcriptome analysis reveals the cellular . . . In this study, we comprehensively charted the cellular landscape of colorectal cancer (CRC) and well-matched liver metastatic CRC using single-cell and spatial transcriptome RNA sequencing We generated 41,892 CD45<sup>-< sup> nonimmune cells and 196,473 CD45<sup>+< sup> immune cells from 27 samples …
Single-cell RNA-sequencing atlas reveals an FABP1-dependent . . . FABP1 exhibited high enrichment in TAMs in metastatic HCC tissues Since FABP1 can promote the progression of HCC, we wonder whether FABP1 can impact the metastatic liver cancer process We analyzed an analysis on the single-cell RNA data found in GSE164522, which came from primary colorectal cancer (CRC) as well as liver metastases
Single-cell RNA-sequencing atlas reveals an FABP1-dependent . . . ScRNA-seq atlas revealed an FABP1-dependent immunosuppressive environment in HCC Orlistat significantly inhibited FABP1 activity, while the combination of anti-PD-1 could synergistically treat HCC progression This study identified new treatment targets and strategies for HCC progression, contribut …
Single-cell transcriptomic analysis deciphers heterogenous cancer stem . . . Objective: Metastasis is the major cause of cancer death However, what types of heterogenous cancer cells in primary tumour and how they metastasise to the target organs remain largely undiscovered Design: We performed single-cell RNA sequencing and spatial transcriptomic analysis in primary colorectal cancer (CRC) and metastases in the liver (lCRC) or ovary (oCRC) We also conducted