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Pathology Outlines - Endometrial hyperplasia Endometrial hyperplasia endometrioid intraepithelial neoplasia (EIN) is a proliferation of endometrial glands with a resulting increase in gland to stroma ratio
Pathology Outlines - Endometrial polyp Endometrial polyp is a benign hyperplastic overgrowth of endometrial tissue that forms a localized projection into the endometrial cavity and is composed of a
Pathology Outlines - Abnormal uterine bleeding Abnormal uterine bleeding is a clinical, not pathological, diagnosis and leads to large numbers of endometrial biopsies, accounting for most endometrial biopsies encountered in practice After ruling out significant endometrial pathology that can lead to abnormal uterine bleeding (e g , endometrial polyp, hyperplasia, atypical hyperplasia, carcinoma, leiomyoma [submucosal], endometrial stromal
Pathology Outlines - Progestin therapy related changes Endometrium with changes consistent with exogenous progestin therapy Comment: Changes are not diagnostic of endometrioid intraepithelial neoplasia atypical hyperplasia or carcinoma but in context, likely represent residual endometrioid neoplasia with progestin therapy related changes Endometrium, biopsy curettage:
Pathology Outlines - Endocervical polyp An endocervical polyp is a benign, exophytic proliferation composed of a variable admixture of endocervical glandular and metaplastic squamous epithelium with a fibrovascular core
Pathology Outlines - Microglandular hyperplasia Benign lesion not requiring treatment Usually incidental microscopic finding in reproductive women Associated with hormonal exposure (pregnancy, postpartum, oral contraceptive pills, hormone replacement therapy) May mimic cervical and endometrial adenocarcinomas
Pathology Outlines - Endometrioid carcinoma Background endometrium with extensive atypical hyperplasia endometrioid intraepithelial neoplasia Uterus and cervix, hysterectomy: Endometrial endometrioid adenocarcinoma, FIGO grade 1, with deep myometrial invasion (> 50%), focal lymphovascular invasion and extension to lower uterine segment (see synoptic report and comment)
Pathology Outlines - Disordered proliferative Differential diagnosis Proliferative endometrium: Irregular glands may be present but only focal (< 10%) and small and only mildly dilated Vast majority of glands: round donut or straight tubular shape, lined with tall pseudostratified columnar epithelium; mitotic figures commonly seen Endometrial hyperplasia without atypia:
Pathology Outlines - Leydig cell hyperplasia Benign microscopic nodules of Leydig (hilus) cells in ovarian hilum; polygonal cells with abundant eosinophilic cytoplasm and Reinke crystals, closely associated with neurovasculature
Pathology Outlines - Endometrial carcinoma-general Microscopic (histologic) description Pathologic definition of carcinoma of the endometrium: Diagnosis of carcinoma is based on features indicative of invasion into the surrounding mesenchyme (endometrial stroma or myometrium)