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Engineering Bispecific Exosomes to Activate T Cells The team behind this innovation capitalized on a newly developed exosome-based platform termed the “Bispecific Exosome Activator of T cells,” or BEAT This system ingeniously co-displays two distinct inhibitory ligands on the surface of inhalable exosomes, enabling concurrent targeting of PD-L1—a prominent immune checkpoint molecule—and Wnt7b, a key mediator of Wnt β-catenin signaling
Click chemistry-based modified exosomes: Towards enhancing precision in . . . Exosome-based therapies are at the forefront of precision medicine, offering targeted drug delivery and personalized treatments specifically for cancer Addressing challenges such as exosome heterogeneity and pH stability is crucial for optimizing therapeutic efficacy
Exosomes from Cancer Cells: Innovative Approach for Targeted Cancer . . . Most of the in vivo and in vitro experiments for exosome-based cancer therapy proved the capabilities of exosomes for transporting nucleic acids or drugs These approaches were developed to target cancer cells and minimize the side effects of therapeutic agents
Our Research - University of California, San Diego Structural and Functional Genomics focuses on classical and molecular genetics and systems biology approaches in the study of cancer, both for understanding the genetic basis of the disease and to identify targets for therapeutic intervention