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Ten-Year Outcome of a Randomized Trial: Cytoreduction and HIPEC with . . . Background Appendiceal cancer is a rare disease that has proven difficult to study in prospectively Our initial report of this trial showed minor hematologic toxicity with both mitomycin C and oxaliplatin and similar 3-year survival We now report an update of the first prospective randomized trial for appendiceal cancer with 10-year follow up Patients and Methods Patients with mucinous
Mucinous appendiceal neoplasms: classification, imaging, and HIPEC . . . Recent advances, specifically cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS HIPEC), offer advantages compared to the traditional therapeutic approach of systemic chemotherapy in the treatment of peritoneal carcinomatosis from mucinous appendiceal neoplasms (MAN)
Staging of appendiceal mucinous neoplasms: challenges and recent . . . The standard of care for the treatment of peritoneal involvement of low-grade appendiceal mucinous neoplasms is cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) Cytoreductive surgery is performed with the intention to remove macroscopic peritoneal disease, whereas the HIPEC allows for a high concentration of
Appendiceal Mucinous Neoplasms: Diagnosis and Management Appendiceal mucinous neoplasms are a heterogeneous group of tumors with a rising incidence Treatment is based on stage and histology Low‐grade tumors are treated surgically with resection of the primary site in early stage disease, or peritoneal debulking and HIPEC in patients with advanced stage disease
Invited Commentary: Ten-Year Outcome of a Randomized Trial . . . - Springer The current publication in Annals of Surgical Oncology by Levine and colleagues reports the long-term outcomes of 121 patients with peritoneal metastases from appendiceal neoplasm who underwent cytoreduction and were then randomly assigned to receive hyperthermic intraperitoneal chemotherapy (HIPEC) with mitomycin C or oxaliplatin Their original publication from 2018 reported short-term
Appendiceal mucinous lesions - UpToDate Appendiceal mucinous neoplasms are rare, with an estimated 3500 cases diagnosed annually in the United States (CRS) and heated intraperitoneal chemotherapy (HIPEC) to treat peritoneal disease This area of practice is not standardized and is actively evolving 1-Year Outcomes of the Peri-Appendicitis Acuta Randomized Clinical Trial
Mucinous appendiceal neoplasms: Report of a case and brief literature . . . Histology demonstrated a high grade appendiceal mucinous neoplasm limited to submucosa (pT3), with concomitant acute phlegmonous appendicitis The decision to perform a preventive HIPEC was made for the young age of the patient with relatively low operative risk, and the presence of lake of mucus in the subserosa Histology of the second
Treatment and Management of Peritoneal Spread from Appendiceal Neoplasms Appendiceal neoplasms are rare and account for less than 1% of all cancers and have been noted in 1% to 1 5% of appendectomy specimens 1 When not found incidentally on imaging, these neoplasms are known to frequently mimic appendicitis or cause abdominal discomfort due to large volume mucinous ascites The malignant potential is variable and dependent on the histologic characteristics of the
Appendicealmucinous neoplasms: Diagnosis andmanagement Conclusion Appendiceal mucinous neoplasms are a heterogeneous group of tumors with a rising incidence Treatment is based on stage and histology Low-grade tumors are treated surgically with resection of the primary site in early stage disease, or peritoneal debulking and HIPEC in patients with advanced stage disease
Mucinous appendiceal neoplasms: classification, imaging, and HIPEC Recent advances, specifically cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS HIPEC), offer advantages compared to the traditional therapeutic approach of systemic chemotherapy in the treatment of peritoneal carcinomatosis from mucinous appendiceal neoplasms (MAN) This review provides an up-to-date, comprehensive summary of the histologic classification of MAN