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Alectinib in Resected ALK-Positive Non–Small-Cell Lung Cancer Platinum-based chemotherapy is the recommended adjuvant treatment for patients with resectable, ALK-positive non–small-cell lung cancer (NSCLC) Data on the efficacy and safety of adjuvant
ALK+ NSCLC Treatment Guidelines Use of ALK TKIs is effective for treatment of patients with ALK+ NSCLC and CNS involvement, and evidence supports alectinib, brigatinib or ceritinib in this setting as first-line therapy
PubMed Central (PMC) We would like to show you a description here but the site won’t allow us
Anaplastic lymphoma kinase (ALK)-positive advanced non-small . . . The molecular pathogenesis, clinical features, and treatment of NSCLC associated with the ALK fusion oncogene are discussed here An overview of the treatment of metastatic NSCLC, ALK-positive early NSCLC, and the methods and indications for molecular testing are presented elsewhere
A Study of Gilteritinib in Adults With Advanced ALK-positive . . . Gilteritinib is an approved treatment for people with acute myeloid leukemia (AML) with the faulty FLT3 gene who haven't responded to previous treatment, or their cancer came back after previous treatment Gilteritinib also blocks changes in the ALK gene which could help people with ALK-positive NSCLC
New Targeted Therapy Strategies for Addressing Non-Small Cell . . . ALK-Fusion Positive Lung Cancer ALK fusions occur in up to 5% of patients diagnosed with NSCLC (10) Six tyrosine kinase inhibitors (TKIs) spanning three generations have been approved for ALK fusion-positive NSCLC As initial therapy, all of these agents produce ORRs from 70% to 80%, and each successive generation has improved CNS activity and median PFS However, effective treatment
Real-world treatment sequencing and effectiveness of second . . . With multiple targeted therapies approved for anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC), it is increasingly important to understand outcomes with various sequences of next-generation ALK tyrosine kinase inhibitors (TKIs) We describe contemporary sequencing patterns and treatment effectiveness of first-line (1L) and second-line (2L) treatments in
Emerging Strategies for ALK+ NSCLC - OncLive EP 1 ALK Alterations and Treatment Options for ALK+ NSCLC EP 2 Long-Term Data in ALK+ NSCLC EP 3 Spotlight on ROS1-Targeted Therapies in Advanced NSCLC EP 4 Treatment Options for ROS1
Frontline Treatment Decisions in ALK+ NSCLC | Oncology . . . The treatment landscape for ALK -positive advanced NSCLC has been revolutionized by the availability of highly effective second- and third-generation ALK inhibitors, each offering distinct efficacy and toxicity profiles that influence treatment selection