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- Hexokinase 2 senses fructose in tumor-associated . . . - Cell Press
Here, we show that a modest amount of fructose, without affecting obesity and associated complications, promotes colorectal cancer tumorigenesis and growth by suppressing the polarization of M1-like macrophages Fructose inhibits M1-like macrophage polarization independently of fructose-mediated metabolism
- Fructose reprogrammes glutamine-dependent oxidative metabolism to . . .
Here, we show that fructose reprograms cellular metabolic pathways to favour glutaminolysis and oxidative metabolism, which are required to support increased inflammatory cytokine production in
- P06. 03. A 永生化巨噬细胞作为体外研究吞噬作用和极化的 . . .
为了评估吞噬能力, 将 BMDM 与经过 HSV-TK 更昔洛韦 (GCV) 自杀基因疗法处理的小鼠 GBM 细胞系 (GL261) 的凋亡小体一起孵育。 通过荧光显微镜和流式细胞术测量吞噬作用。
- Identification and biochemical characterization of the fructokinase . . .
Fructose is an abundant sugar in plants as it is a breakdown product of both major sucrose-cleaving enzymes To enter metabolism, fructose is phosphorylated by a fructokinase (FRK) Known FRKs are members of a diverse family of carbohydrate purine kinases known as the phosphofructokinase B (pfkB) family
- Fructokinase - an overview | ScienceDirect Topics
In the fructose metabolic pathway, KHK, also known as fructokinase, the first rate-limiting metabolic enzyme, catalyzes the conversion of fructose and ATP to fructose 1-phosphate (F1P) and ADP, respectively
- TAK1信号通路在高糖诱导骨髓来源巨噬细胞激活中的作用
本研究拟采用TAK1特异性抑制剂5Z-7-oxozeaenol作用于高糖培养的骨髓来源巨噬细胞(bone marrow-derived macrophages,BMDM ),观察高糖刺激BMDM后巨噬细胞活化情况和TAK1通路相关蛋白表达及5Z-7-oxozeaenol抑制作用的影响,初步探讨TAK1信号
- Genome-wide identification, molecular evolution, and . . .
Fructokinase (FRK) is a regulator of fructose signaling in plants and gateway proteins that catalyze the initial step in fructose metabolism through phosphorylation Our previous study demonstrated that MdFRK2 protein exhibit not only high affinity for fructose, but also high enzymatic activity due to sorbitol
- Growing Murine Bone Marrow-Derived Macrophages - PubMed
Bone marrow-derived macrophages (BMDM) are primary macrophages obtained by in vitro differentiation of bone marrow cells in the presence of macrophage colony-stimulating factor (M-CSF or CSF1) They are easy to obtain in high yields, can be stored by freezing, and can be obtained from genetically mo …
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