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Brain Banks - ALZFORUM The brain bank accepts donations from residents of Quebec Province with longitudinal or clinical records Phenotypes collected for most neurodegenerative diseases, healthy brain, mental disorders, and suicide victims Whole brain, hemisphere, and some spinal cord tissues are available to researchers fixed, frozen, and sometimes block
Banner Sun Health Research Institute - ALZFORUM This brain bank, biobank, and biospecimen bank derives its donors from the Arizona Study of Aging and Neurodegenerative Disease (AZSAND), a longitudinal clinicopathological study of elderly volunteers living in Maricopa county and metropolitan Phoenix Studies focus on Alzheimer’s and Parkinson
Brain Banks for Alzheimer’s, Parkinson’s Remain Underused Related disorders include DLB, Parkinson’s disease with dementia, multiple system atrophy, and progressive supranuclear palsy Banner recently joined the Parkinson’s Disease Biomarkers Program, a new portal that will enable researchers to submit requests for biomarker data and associated tissue requests to the Banner brain bank, Sieber said
Can Human Cytomegalovirus Infections Spark Alzheimer’s Pathology? A growing body of work implicates infections as a risk factor for Alzheimer’s disease In the December 19 Alzheimer’s Dementia, scientists led by Benjamin Readhead at Arizona State University, Tempe, and Eric Reiman at Banner Alzheimer’s Institute, Phoenix, add the latest evidence In
GNPC: Mining 40,000 Fluid Samples for Neurodegeneration Markers GNPC has assembled proteomic data on 40,000 blood and CSF samples from cohorts of neurodegenerative disease The dataset will be released for public use July 15 GNPC scientists are adding more proteomic platforms and ethnic diversity for the next version
TDP-43 Conference Marks Concerted Effort to Finally Snag Biomarkers He is working with Banner Alzheimer’s Institute in Phoenix to develop an immunoassay that will employ one of the monoclonals to capture cryptic HDGFL2, and a different one to detect it, heightening the test’s specificity
Microglial Transcriptome Hints at Shortcomings of AD Model The researchers also examined microglial expression in human AD tissue They sequenced RNA from previously frozen samples of the fusiform gyrus from 33 Braak stage I-IV and 84 Braak stage III-VI cases from the Banner Research Institute tissue bank The AD samples scored about 10 percent higher for the neurodegeneration module
Umibecestat - ALZFORUM In August 2017, Novartis and API Banner Alzheimer’s Institute began an additional Phase 2 3 prevention study GENERATION 2 is aiming to enroll 2,000 cognitively normal homozygous ApoE4 carriers, or heterozygous carriers with evidence of brain amyloid, age 65 to 70
Massive Proteomics Studies Peg Glial Metabolism, Myelination . . . - ALZFORUM For their initial analysis, they compared levels of more than 3,000 proteins in 453 dorsolateral prefrontal cortex samples from four well-characterized cohorts: the Baltimore Longitudinal Study of Aging (BLSA), the Banner Sun Health Research Institute, Mount Sinai School of Medicine Brain Bank, and Adult Changes in Thought Study (ACT)