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BRCA Gene Changes: Cancer Risk and Genetic Testing A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing
BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute Evidence-based, expert-reviewed summary about the BRCA1 and BRCA2 genes and hereditary breast and ovarian cancer This summary also contains information about the cancer risks associated with BRCA1 BRCA2, screening, risk-reduction, treatment, and prognosis
MRI, Surgery Reduce Cancer Deaths in Women with BRCA Changes For women with inherited harmful changes in BRCA genes, MRI surveillance and salpingo-oophorectomy can modestly reduce their risk of dying from breast and ovarian cancer, results from two studies show
Surgery to Reduce the Risk of Breast Cancer A fact sheet that describes mastectomy and salpingo-oophorectomy, two surgeries that may be used to reduce the risks of breast and ovarian cancers in people, and nonsurgical options
Discovery – BRCA Connection to Breast and Ovarian Cancer NCI-funded research helped identify inherited BRCA1 and BRCA2 genetic mutations and their connection to breast and ovarian cancer From this research, a screening test was also developed to help patients make informed decisions about their health
PALB2 and Associated Cancer Risks (PDQ®) - NCI Evidence-based, expert-reviewed summary about the PALB2 gene, the cancer risks associated with PALB2, screening, risk-reduction, treatment, and prognosis
Olaparib Approved for Breast Cancers with BRCA Gene Mutations The Food and Drug Administration has approved olaparib (Lynparza®) to treat metastatic breast cancers that have inherited mutations in the BRCA1 or BRCA2 genes as well as a companion diagnostic test for selecting candidates for the therapy