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Parkin S65A KI Mouse | ALZFORUM This constitutive KI mouse model was generated by Flp-mediated homologous recombination in mouse embryonic stem cells to introduce an S65A point mutation in exon 3 of the Park2 (Parkin) gene (McWilliams et al , 2018) These knock-in (KI) mice carry a serine to alanine mutation (S65A) in the N
Parkin Q311X Mouse (BAC Tg) | ALZFORUM The Q311X mutation is a nonsense mutation that produces a C-terminally truncated parkin, just 155 amino acids long Parkin-Q311X mice (line A) have two copies of the transgene (Tg) integrated in tandem in a bacterial artificial chromosome (BAC), although its integration site is unknown Notably, as
ALS-Linked Kinase Promotes Mitochondrial Destruction Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress Neuron 2015 Jul 15;87 (2):371-81 PubMed Juvenile Lysosomes and Worn-Out Mitochondria Clog Axons in ALS Model Optineurin Mutations Cause ALS, If Not Glaucoma Parkinsonism-linked Protein Binds Parkin and Pink1, Drives Mitophagy
Dopamine covalently modifies and functionally inactivates parkin . . . Therefore, the authors proposed that parkin is a direct molecular target of oxidized dopamine, and the dopamine-induced loss of parkin activity represented a possible mechanism of the selective neurodegeneration in PD
Loss of Parkin reduces inflammatory arthritis by inhibiting p53 . . . Jung YY, Son DJ, Lee HL, Kim DH, Song MJ, Ham YW, Kim Y, Han SB, Park MH, Hong JT Loss of Parkin reduces inflammatory arthritis by inhibiting p53 degradation Redox Biol 2017 Aug;12:666-673 Epub 2017 Apr 5 PubMed
Curcuma wenyujin extract alleviates cognitive deficits and restrains . . . Qi Y, Zhang J, Zhang Y, Zhu H, Wang J, Xu X, Jin S, Wang C, Zhang F, Zhao M, Wu Z, Zhu H, Yan P Curcuma wenyujin extract alleviates cognitive deficits and restrains pyroptosis through PINK1 Parkin mediated autophagy in Alzheimer's disease
Pink1 KO Rat - ALZFORUM Moreover, in Pink1 KO rats, the mitochondrial proteome in non-synaptic striatal samples exhibited 15 differentially expressed proteins compared with DJ-1 and Parkin KO rats at 3 months of age
Parkin absence accelerates microtubule aging in dopaminergic neurons . . . Cartelli D, Amadeo A, Calogero AM, Casagrande FV, De Gregorio C, Gioria M, Kuzumaki N, Costa I, Sassone J, Ciammola A, Hattori N, Okano H, Goldwurm S, Roybon L, Pezzoli G, Cappelletti G Parkin absence accelerates microtubule aging in dopaminergic neurons