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Glutamate dehydrogenase - Wikipedia Glutamate dehydrogenase (GLDH, GDH) is an enzyme observed in both prokaryotes and eukaryotic mitochondria The aforementioned reaction also yields ammonia, which in eukaryotes is canonically processed as a substrate in the urea cycle Typically, the α-ketoglutarate to glutamate reaction does not occur in mammals, as glutamate dehydrogenase equilibrium favours the production of ammonia and α
Glutamate Dehydrogenase - an overview | ScienceDirect Topics Glutamate dehydrogenase (GDH) is defined as a mitochondrial enzyme involved in the metabolism of glutamate to 2-oxoglutarate, primarily found in the liver, kidney, and cardiac muscle Increased serum levels of GDH can indicate liver damage or necrosis AI generated definition based on: The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents, 2012